NPB Neurobiology, Physiology & Behavior

James S. Trimmer
James S. Trimmer
Professor
1009 Life Sciences
Office: 530.754.6075
Lab: 530.754.6076

Fax: 530.754.6079
jtrimmer (at) ucdavis (dot) edu
NeuroMab

Degrees:
BS., University of California, San Diego, 1981
PhD., University of California, San Diego, Marine Biology, 1987

Awards:
American Heart Association Established Investigator Award, 1994-1999
Jacob Javits Neuroscience Investigator (MERIT) Award, National Institute of Neurological Diseases and Stroke, National Institutes of Health, 2000-2007


Department and Center Affiliations:
Center for Neuroscience
Department of Physiology and Membrane Biology (School of Medicine)

Professional Societies:
Society for Neuroscience

American Society for Cell Biology

Biophysical Society


Grad Group Affiliations:
Neuroscience
Biochemistry and Molecular Biology
Cell and Developmental Biology

Publications (since 2007):
Van Wart, A., Trimmer, J. S., and G. Matthews. (2007). Polarized Distribution of Ion Channels Within Microdomains of the Axon J. Comp. Neurol. 500:339-352.

Vacher, H., Mohapatra, D. P., Misonou, H, and J. S. Trimmer. (2007). Regulation of Kv1 Channel Trafficking by the Mamba Snake Neurotoxin Dendrotoxin K. FASEB J. 21:906-914. Faculty of 1000 Biology: http://www.f1000biology.com/article/id/1058723/evaluation

Rasmussen, H. B., Frøkjær-Jensen, C., Jensen, C. S., Jensen, H. S., Jørgensen, N. K., Misonou, H., Trimmer, J. S., Olesen, S.-P., and N. Schmitt. (2007). Requirement of Subunit Co-Assembly and Ankyrin-G for M Channel Localization at the Axon Initial Segment. J. Cell 120:953-963.

Mohapatra, D. P., Vacher, H., and J. S. Trimmer. (2007). The Surprising Catch of a Voltage-Gated Potassium Channel in a Neuronal SNARE. Science STKE: pe37.

Park, K.-S., Mohapatra, D. P., and J. S. Trimmer. (2007). Proteomic Analyses of Kv2.1 Channel Phosphorylation Sites Determining Cell Background-Specific Differences in Function. Channels 1: 59-61.

Yang, J.-W., Vacher, H., Park, K.-S., Clark, E, and J. S. Trimmer. (2007). Trafficking-dependent Phosphorylation of Kv1.2 Regulates Voltage-gated Potassium Channel Cell Surface Expression. Proc. Nat. Acad. Sci. USA 104: 20055-20060. http://www.pnas.org/cgi/doi/10.1073/pnas.0708574104

Park, K. S., Yang, J. W., Seikel, E., and J. S. Trimmer (2008).  Potassium Channel Phosphorylation in Excitable Cells: Providing Dynamic Functional Variability to a Diverse Family of Ion Channels. Physiology 23:49-57.

Mohapatra, D. P., Siino, D. F., and J. S. Trimmer. (2008). Interdomain Cytoplasmic Interactions Govern the Intracellular Trafficking, Gating and Modulation of the Kv2.1 Channel. J. Neurosci. 28: 4982-4994.

Rhodes K.J., and J.S. Trimmer (2008). Antibody-based validation of CNS ion channel drug targets. J Gen Physiol. 131(5):407-13.

Menegola M., Misonou H., Vacher H., and J.S. Trimmer (2008). Dendritic A-type potassium channel subunit expression in CA1 hippocampal interneurons. Neuroscience 154(3):953-64. 

Ogawa Y., Horresh I., Trimmer J.S., Bredt D.S., Peles E., and M.N. Rasband (2008). Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2. J Neurosci. 28(22):5731-9.

Yan J., Olsen J.V., Park K.S., Li W., Bildl W., Schulte U., Aldrich R.W., Fakler B., and J.S. Trimmer (2008). Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity. Mol Cell Proteomics 7(11):2188-98.

Martinez H.D., Jasavala R.J., Hinkson I., Fitzgerald L.D., Trimmer J.S., Kung H.J., and M.E. Wright (2008). RNA editing of androgen receptor gene transcripts in prostate cancer cells. J Biol Chem. 283(44):29938-49.

Monaghan M.M., Menegola M., Vacher H., Rhodes K.J., and J.S. Trimmer (2008). Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy. Neuroscience 156(3):550-62. 

Rasband, M. N., and J. S. Trimmer. (2008). Ion Channel Localization in Axons. (pp. 229-235). In Encyclopedia of Neuroscience. (L. R. Squire, ed.). Elsevier Academic Press, London.

Vacher H., Mohapatra D.P., and J.S. Trimmer (2008). Localization and targeting of voltage-dependent ion channels in mammalian central neurons. Physiol Rev. 88(4):1407-47.

Mohapatra, D. P., Misonou, H, Pan, S.-J., Held, J. E., Surmeier, D. J., and J. S. Trimmer. (2009). Modulation of the Kv2.1 Potassium Channel Contributes to Activity-Dependent Regulation of Intrinsic Excitability in Hippocampal Neurons. Channels 3: 46-56.

Vacher, H., and J. S. Trimmer. (2009). Shaker Family Kv1 Voltage-gated Potassium Channels in Mammalian Brain Neurons. (Chapter 5, pp. 127-154). In Structure, Function and Modulation of Neuronal Voltage Gated Ion Channels. (V. Gribkoff and L. K. Kaczmarek, Editors). John Wiley and Sons, Hoboken.

Mikula, S., Parrish, S. K., Trimmer, J. S., and E. G. Jones. (2009). Complete 3D Visualization of Primate Striosomes by KChIP1 Immunostaining. J. Comp. Neurol. 514: 507-517.

Research Interests:
We are interested in how neurons regulate electrical excitability through effects on ion channel expression, localization and function, and how these are dynamically modulated in development and disease, and in response to neuromodulation and activity.

Laboratory Personnel:
Trimmer laboratory / 1111 Life Sciences  -   Jesus Aguado (junior specialist), Angeliki Bundros (undergrad), Oscar Cerda (postdoc),  Fabio Iannotti (visiting graduate student), Moon Young Kim (postdoc), Luci Lopez (postdoc), Danielle Mandikian (BMB graduate student), Colleen Manning (staff research associate), Danielle Pannebaker (undergrad), Jon Sack (postdoc)

Teaching Interests:
Cellular Neuroscience, Cell Signaling

Courses Taught:
NSC 221 Cellular Neuroscience - Term(s): Fall
NPB107  Cell Signaling in Health and Disease - Term(s): Winter